Ethyl 2-oxo-2-(thiophen-2-yl)acetate CAS 4075-58-5
Ethyl 2-oxo-2-(thiophen{2}}yl)acetate CAS 4075-58-5 yog dab tsi?
Ethyl 2-oxo-2-(thiophen-2-yl)acetate CAS 4075-58-5 feem ntau yog siv los ua cov tshuaj tiv thaiv substrate lossis reagent hauv cov organic synthesis thiab tuaj yeem siv los ua ke lwm cov organic compounds, xws li thioheterocyclic compounds. Nws muaj qee yam haujlwm thiab tuaj yeem koom nrog ntau hom tshuaj tiv thaiv, xws li esterification, nucleophilic hloov pauv, thiab lwm yam.
Vim Li Cas Xaiv Peb
Peb lub Hoobkas
Sichuan Biosynce Pharmaceutical Technology Co., Ltd. tau tsim muaj nyob rau hauv 2008. Biosynce tshwj xeeb hauv kev tsim, muab thiab kev lag luam ntawm cov tshuaj intermediates, API thiab cov khoom siv tshuaj zoo.
Peb cov khoom
Peb cov khoom muaj xws li Pyrrole Series, Piperazine Series, Pyridine Series, Quinoline Series thiab Piperidine Series, kuj peb muab CDMO, CRO thiab customized synthesis kev pab rau cov neeg siv khoom hauv tsev thiab txawv teb chaws.
R&D
Peb pab pawg R & D yog tsim los ntawm cov kws tshaj lij thiab cov kws tshaj lij thiab cov kws tshaj lij, nrog thawj chav kawm hauv tsev thiab txawv teb chaws kev lag luam kws tshuaj chemistry keeb kwm, nplua nuj R & D thiab kev tswj hwm kev paub. Peb tuaj yeem hloov kho lub tsev qiv ntawv khoom raws li cov neeg siv khoom xav tau, thiab muab ntau tshaj li ntau txhiab cov khoom hauv Tshuag, nrog rau ntim xws li grams mus rau tons, thiab cov khoom lag luam tshiab tau ntxiv txhua hnub.
Kev tsim khoom lag luam
Biosynce muaj ib qho kev ywj pheej R & D thiab chaw soj ntsuam nruj me ntsis kuaj cov khoom zoo thiab muab cov neeg siv khoom zoo, peb cov khoom tau xa tawm mus rau North America, Europe, Asia thiab Africa. Peb lub hom phiaj los tsim kom muaj kev sib raug zoo nrog cov neeg siv khoom mus sij hawm ntev thiab muaj txiaj ntsig zoo thiab muab cov khoom zoo thiab cov kev pabcuam zoo.
Xav txog lawv cov kev ruaj khov siab, thiophenes tshwm sim los ntawm ntau qhov kev cuam tshuam nrog cov khoom siv sulfur thiab hydrocarbons, tshwj xeeb tshaj yog cov tsis muaj dej txaus. Thawj qhov kev sib txuas ntawm thiophene los ntawm Meyer, qhia tib lub xyoo uas nws tau tshawb pom, suav nrog acetylene thiab elemental sulfur. Thiophenes yog classical npaj los ntawm cov tshuaj tiv thaiv ntawm 1, 4-diketones, diesters, los yog dicarboxylates nrog sulfidizing reagents xws li P4S10 xws li hauv Paal-Knorr thiophene synthesis. Tshwj xeeb thiophenes tuaj yeem ua ke zoo ib yam siv Lawesson's reagent raws li tus neeg sawv cev sulfidizing, lossis los ntawm Gewald cov tshuaj tiv thaiv, uas cuam tshuam nrog cov condensation ntawm ob esters nyob rau hauv muaj cov tshuaj sulfur. Lwm txoj kev yog Volhard-Erdmann cyclization.
Thiophene yog tsim los ntawm qhov ntsuas me me ntawm ib ncig ntawm 2, 000 metric tons hauv ib xyoos thoob ntiaj teb. Kev tsim khoom suav nrog cov tshuaj tiv thaiv theem vapor ntawm ib qho sulfur, feem ntau carbon disulfide, thiab C -4 qhov chaw, feem ntau butanol. Cov reagents no tau tiv nrog oxide catalyst ntawm 500-550 degree.
Specification ntawm Ethyl 2-oxo-2-(2-thienyl)acetate
Ethyl thiophene-2-glyoxylate (4075-58-5) kuj tuaj yeem hu ua Ethyl-2-thiopheneglyoxylate ; Ethyl alpha-oxothiophen -2-acetate ; Thiophene -2-glyoxylic acid ethyl ester ; Ethyl 2-oxo-2-(2-thienyl)acetate .Nws yog qhov phom sij, yog li kev pab thawj zaug thiab lwm yam yuav tsum paub. Xws li: Thaum ntawm daim tawv nqaij: ua ntej, yuav tsum yaug daim tawv nqaij nrog dej txaus tam sim ntawd tsawg kawg 15 feeb thaum tshem cov khaub ncaws tsis huv. Thib ob, Tau txais kev pab kho mob khau. Los yog hauv qhov muag: yaug qhov muag nrog dej kom tsawg li 15 feeb, qee zaus nqa daim tawv muag sab sauv thiab sab qis.Tom qab ntawd tau txais kev pab kho mob sai sai.Thaum, nws nqus tau: Tshem tawm ntawm qhov raug thiab txav mus rau huab cua ntshiab tam sim. tsis ua pa. Thaum ua pa nyuaj, muab cov pa oxygen. Thiab sai li sai tau kom tau txais kev pab kho mob. Tom qab ntawd koj tau noj cov khoom no: Ntxuav lub qhov ncauj tawm nrog dej, thiab tau txais kev pab kho mob tam sim ntawd.Ceeb toom rau tus kws kho mob: Kho kev txhawb nqa thiab cov tsos mob.
Tsis tas li ntawd, Ethyl thiophene -2-glyoxylate (4075-58-5) tuaj yeem ruaj khov nyob rau hauv qhov kub thiab txias thiab lub zog siab.Nws tsis sib haum nrog cov muaj zog oxidizing tus neeg sawv cev, qhov chaw hluav taws kub, muaj zog acids, muaj zog hauv paus, thiab koj yuav tsum tsis txhob coj nws nrog cov ntaub ntawv tsis sib xws.Thiab tiv thaiv nws kom tawg mus rau hauv cov khoom puas tsuaj: khaus thiab cov pa phem thiab cov pa roj carbon dioxide, carbon monoxide.
Kev kho mob tseem ceeb ntawm hluavtaws thiophene
Thiophene thiab nws cov derivatives hloov pauv yog cov chav kawm tseem ceeb heev ntawm cov tshuaj heterocyclic uas qhia tau hais tias nthuav dav hauv kev siv tshuaj chemistry. Nws tau ua ib qho tseem ceeb thauj tog rau nkoj rau cov kws tshuaj kho mob los tsim cov tsev qiv ntawv sib xyaw ua ke thiab ua tiav kev siv zog hauv kev tshawb nrhiav cov hlau lead molecules. Nws tau raug tshaj tawm tias muaj ntau yam kev kho mob nrog ntau hom kev siv hauv tshuaj chemistry thiab cov ntaub ntawv tshawb fawb, nyiam kev txaus siab hauv kev lag luam thiab kev kawm.
Nws tau raug pov thawj tias yog cov tshuaj muaj txiaj ntsig hauv cov xwm txheej tam sim no. Lawv yog cov zoo kawg li cov tebchaw ob qho tib si nrog rau lawv cov kev lom zem thiab lub cev muaj zog xws li tshuaj tiv thaiv kab mob, tiv thaiv kev puas siab puas ntsws, tiv thaiv arrhythmic, tiv thaiv kev ntxhov siab, tiv thaiv kab mob, antioxidant, estrogen receptor modulating, anti-mitotic, anti-microbial, kinases inhibiting thiab anti-cancer.
Yog li cov synthesis thiab tus cwj pwm ntawm cov tshiab thiophene moieties nrog kev kho mob dav dua yog lub ntsiab lus ntawm kev txaus siab rau cov kws kho mob tshuaj los ua ke thiab tshawb xyuas cov qauv qauv tshiab nrog kev ua haujlwm zoo dua qub. Txawm li cas los xij, ntau cov tshuaj muaj muag xws li Tipepidine, Tiquizium Bromides, Timepidium Bromide, Dorzolamide, Tioconazole, Citizolam, Sertaconazole Nitrate thiab Benocyclidine kuj muaj thiophene nucleus.
Thiophene tau pom los ua ib qho kab mob hauv benzene. Nws muaj cov molecular loj ntawm 84.14 g / mol, ceev yog 1.051 g / ml thiab Melting Point yog - 38 degree. Nws yog soluble hauv feem ntau cov kuab tshuaj organic xws li cawv thiab ether tab sis insoluble hauv dej. Cov "electron khub" ntawm leej faj yog cov delocalized nyob rau hauv lub π electron system thiab coj tsis tshua muaj reactive zoo li benzene derivative. Thiophene tsim cov azeotrope nrog ethanol zoo li benzene. Qhov zoo sib xws ntawm physicochemical zog ntawm benzene thiab thiophene yog qhov zoo kawg li. Piv txwv li, qhov kub ntawm benzene yog 81.1 degree thiab thiophene yog 84.4 degree (ntawm 760 mmHg) thiab yog li ntawd, ob qho tib si yog ib qho piv txwv zoo ntawm bioisosterism. Nws tuaj yeem yooj yim sulfonated, nitrated, halogenated, acylated tab sis tsis tuaj yeem ua alkylated thiab oxidized.
Nyob rau hauv tshuaj chemistry, thiophene derivatives yog ib qho tseem ceeb heev heterocycles nthuav tawm cov kev siv zoo kawg nkaus hauv kev qhuab qhia sib txawv. Nyob rau hauv cov tshuaj, thiophene derivatives qhia antimicrobial, analgesic thiab anti-inflammatory, antihypertensive, thiab antitumor kev ua si thaum lawv tseem siv los ua inhibitors ntawm corrosion ntawm hlau los yog nyob rau hauv fabrication ntawm lub teeb-emitting diodes nyob rau hauv cov ntaub ntawv science.
Cov qauv molecular thiab crystal thiab spectroscopic zog ntawm 2-oxo-2-(Thiophen-2-}yl) ethyl phosphonic acid
Phosphonic acid derivatives tau txais cov ntawv thov hauv lub zog cia thiab catalysis. Lawv kuj tau siv nyob rau hauv kev sib pauv ion, enantioselective intercalation cov tshuaj tiv thaiv, thiab nyob rau hauv nws tus kheej-them ntawm nyias films exhibiting electroactive zog. Tsis tas li ntawd, polyelectrolyte daim nyias nyias raws li phosphonic acid derivatives kuj tau tsim thiab pom tias muaj kev cuam tshuam loj heev rau qhov kub thiab txias, nrog rau kev tawm tsam los ntawm cov dawb radicals.
Phosphonic acid derivatives kuj yog cov ntsiab lus nthuav dav los ntawm kev pom ntau dua. Qhov tseeb, qhov yooj yim conformational yooj ntawm lawv pawg hydroxyl thiab lawv lub peev xwm los koom rau hauv intra- thiab/los yog intermolecular H-bond hom kev sib cuam tshuam, ob qho tib si raws li cov neeg txais los yog pub, feem ntau ua rau nthuav cov qauv molecular thiab supramolecular architectures. Cov no tau ntxiv dag zog rau hauv cov xwm txheej uas qhov hloov pauv txuas nrog phosphonic acid moiety kuj tseem muaj cov yam ntxwv ntawm kev tshawb nrhiav nyuaj (xws li, conformational yooj, π-electron delocalization, H-bond forming capability, thiab lwm yam).
Peb cov synthesis ntawm ib tug tshiab phosponic acid, (2-oxo-2-(thiophen-2-} yl)ethyl) phosphonic acid (OTEPA; Scheme 1) tau tshaj tawm, nrog rau nws cov qauv thiab spectroscopic characterization nyob rau theem molecular thiab nyob rau hauv crystalline theem. OTEPA yog ib qho yooj yim phosphonic acid derivative uas phim cov yam ntxwv ntawm cov qauv rau kev nthuav qhia ntau tus conformers (nws muaj tsib qhov sib txawv sab hauv kev sib hloov uas yuav ua rau conformational isomers) thiab ntau hom intra / inter molecular H-hom kev sib cuam tshuam [nws qhia tsib electronegative centres, ntxiv rau lub nplhaib delocalized π-system, uas tuaj yeem ua raws li H-bond txais (electron cov neeg pub dawb), thiab ob pawg OH uas tuaj yeem ua haujlwm raws li H-daim ntawv cog lus pub dawb].
Lub hom phiaj tseem ceeb ntawm tsab xov xwm no yog los ua kom pom qhov sib txawv ntawm qhov tseem ceeb ntawm kev sib cuam tshuam loj- thiab kev sib cuam tshuam uas muaj nyob rau hauv cov molecule cais ntawm cov compound thiab / los yog nyob rau hauv lub crystalline theem. Cov ntaub ntawv no muaj feem cuam tshuam los txhim kho cov kev paub txog cov yam ntxwv ntawm cov qauv thiab cov khoom ntawm phosphonic acid moiety. Qhov chaw conformational ntawm OTEPA molecule tau tshawb xyuas theoretically, thiab cov conformers ruaj khov tshaj plaws yog cov qauv thiab spectroscopically yam ntxwv. Cov txheeb ze ruaj khov ntawm cov conformers tau piav qhia raws li cov yam ntxwv ntawm cov khoom sib xyaw, cov intramolecular H-bond tsim los ntawm ib qho ntawm OH pawg ntawm cov phosphonic acid fragment thiab carbonyl oxygen atom ntawm qhov hloov pauv yog qhov tseem ceeb intramolecular kev sib cuam tshuam lub luag haujlwm rau lub luag haujlwm. stabilization ntawm qis zog conformers ntawm lub compound.
Txaus siab heev, O⋯S kev sib cuag ntawm carbonyl oxygen atom thiab sulfur atom ntawm lub nplhaib thiophene (uas zoo ib yam li N⋯S hom kev sib cuag tau pom yav dhau los hauv lwm lub tshuab molecular) tau pom tias tseem yog ib qho tseem ceeb intramolecular kev cuam tshuam hauv kev txiav txim siab. kev ruaj ntseg ntawm ob lub zog qis tshaj conformers ntawm OTEPA. Ntawm qhov tod tes, nyob rau hauv cov siv lead ua, lub intramolecular H-bond stabilizing lub zog qis tshaj conformers ntawm cais OTEPA molecule yog hloov los ntawm intermolecular H-bonds tsim nrog cov neeg nyob ze molecules, thiaj li hais tias cov xaiv conformations nyob rau hauv lub crystalline theem yog siab dua-zog qauv. thaum sib cais (nrog lub zog siab dua li qhov ruaj khov tshaj plaws conformer ntau dua 13 kJ mol-1). OTEPA tom qab ntawd yog ib qho piv txwv nthuav ntawm ib qho kev sib txuas uas qhia txog kev xaiv ua raws li crystallization uas yuav tsum muaj kev tsim kho ntau yam.
Biosynce muaj ib qho kev ywj pheej R & D thiab chaw soj ntsuam nruj me ntsis kuaj cov khoom zoo thiab muab cov neeg siv khoom zoo, peb cov khoom tau xa tawm mus rau North America, Europe, Asia thiab Africa. Peb lub hom phiaj los tsim kom muaj kev sib raug zoo nrog cov neeg siv khoom mus sij hawm ntev thiab muaj txiaj ntsig zoo thiab muab cov khoom zoo thiab cov kev pabcuam zoo.
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