Nucleophilic Hloov Pyridine

Vim tias electron nqus ntawm nitrogen atom ntawm lub nplhaib pyridine, electron huab ntom ntom ntawm cov pa roj carbon atom ntawm lub nplhaib txo, tshwj xeeb tshaj yog cov huab cua ntom ntom ntawm 2 thiab 4 qhov chaw qis dua, yog li cov nucleophilic hloov pauv cov tshuaj tiv thaiv ntawm lub nplhaib yog. yooj yim tshwm sim, thiab kev hloov pauv cov tshuaj tiv thaiv feem ntau tshwm sim ntawm 2 thiab 4 qhov chaw.
Cov tshuaj tiv thaiv ntawm pyridine nrog sodium amino rau daim ntawv 2-aminopyridine hu ua Chizhibabin cov tshuaj tiv thaiv, thiab yog tias 2 qhov chaw twb tau nyob lawm, cov tshuaj tiv thaiv tshwm sim ntawm 4 qhov chaw kom tau txais 4-aminopyridine, tab sis cov txiaj ntsig qis. . Yog tias muaj ib pab pawg tawm zoo (xws li halogen, nitro) nyob rau hauv los yog txoj hauj lwm ntawm lub nplhaib pyridine, nws yog ib qho yooj yim uas tshwm sim nucleophilic hloov cov tshuaj tiv thaiv. Piv txwv li, pyridine tuaj yeem muaj kev hloov pauv nucleophilic nrog ammonia (lossis amine), alkoxide, dej thiab lwm yam tsis muaj zog nucleophilic reagents.